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Product No.:GMP-TL506-0050
Product No.:100μg / GMP-TL506-0100
Product No.:GMP-TL506-1000(Customized)
038126
CHO cells
IL7,Interleukin-7
A DNA sequence encoding the human IL-7(P13232-1:D26-H177)was expressed with a Fc-tag at the C-terminus.
The recombinant human IL-7 protein predicts a molecular mass of 43.8 kD.
> 95 % as determined by SDS-PAGE and HPLC.
< 0.01EU per 1μg of the protein by the LAL method.
Cell proliferation assay was performed on PBMC cells activated with CD3 monoclonal antibody, with an ED₅₀ of 0.5-20ng/mL and a corresponding specific activity of >1× 10⁷IU/mg (calibrated according to human IL-7 reference standard (NIBSC code: 90/530)).
Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization.
Lyophilized preparation can be stored at -20 ℃. 6 months at -20℃ under sterile conditions after reconstitution. 12 months at -80℃ under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100μg/mL. Avoid repeated freeze-thaw cycles.
IL-7 is an important cytokine for the growth, survival, and differentiation of T, B, and NK cells. The heterodimer formed by IL-7 and hepatocyte growth factor (HGF) is a precursor B cell growth stimulating factor. Studies on gene knockout in mice have shown that IL-7 plays a crucial role in the survival of lymphocytes. IL-7 stimulates pluripotent stem cells to differentiate into lymphoid progenitor cells.
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