Recombinant Human IL-7 Protein-T&L Biotechnology

Product manual COA

Recombinant Human IL-7 Protein

Price：$ 507

Price：$ 817

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Size：

50μg

50μg

100μg

1mg

Product No.：GMP-TL506-0050

Product No.：100μg / GMP-TL506-0100

Product No.：GMP-TL506-1000（Customized）

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Product Information

DMF filed no：
038126
Expression Host：
CHO cells
Synonym：
IL7,Interleukin-7
Protein sequence：
A DNA sequence encoding the human IL-7（P13232-1：D26-H177）was expressed with a Fc-tag at the C-terminus.
Molecular Mass：
The recombinant human IL-7 protein predicts a molecular mass of 43.8 kD.
QC Testing Purity：
> 95 % as determined by SDS-PAGE and HPLC.
Endotoxin：
< 0.01EU per 1μg of the protein by the LAL method.
Activity：
Cell proliferation assay was performed on PBMC cells activated with CD3 monoclonal antibody, with an ED₅₀ of 0.5-20ng/mL and a corresponding specific activity of >1× 10⁷IU/mg (calibrated according to human IL-7 reference standard (NIBSC code: 90/530)).
Formulation：
Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization.
Stability：
Lyophilized preparation can be stored at -20 ℃.
6 months at -20℃ under sterile conditions after reconstitution.
12 months at -80℃ under sterile conditions after reconstitution.
Storage：
Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100μg/mL.
Avoid repeated freeze-thaw cycles.

Background

IL-7 is an important cytokine for the growth, survival, and differentiation of T, B, and NK cells. The heterodimer formed by IL-7 and hepatocyte growth factor (HGF) is a precursor B cell growth stimulating factor. Studies on gene knockout in mice have shown that IL-7 plays a crucial role in the survival of lymphocytes. IL-7 stimulates pluripotent stem cells to differentiate into lymphoid progenitor cells.

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