Anti-Human CD52 mAb-T&L Biotechnology

Product manual COA

Anti-Human CD52 mAb

Price：$ 352

Size：

100μg

100μg

Product No.：GMP-TL112-0100

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Product Information

Expression Host：
HEK293 cells
QC Testing Purity：
> 90 % as determined by SDS-PAGE.
Purification
Protein A purified from cell culture supernatant.
Biological activity：
The binding rate with MC/CAR
Endotoxin：
< 0.1EU per μg of the protein as determined by the LAL method.
Formulation：
Supplied as a 0.22μm filtered solution in PBS, PH 7.4.
Stability & Storage
24 months at 2℃ to 8℃. Avoid repeated freeze-thaw cycles.

产品描述

CD52 is a widely distributed antigen belonging to a GPI anchored glycoprotein with only twelve amino acid residues (GQNDTSQTSSPS). CD52 can be found on the surface of lymphocytes, monocytes,eosophils and dendritic cells in hematopoietic system. with a density of up to 5×10⁵molecules on lymphocytes, CD52 antigens express on many lymphoid cell malignancies and certain acute myeloid leukemia cells. When CD52 molecules are crosslinked with mAb, it triggers a series of signaling within the target cells.The signaling caused by the activation of CD52 molecules is similar to that caused by anti-CD3 antibodies. When CD52 molecules are triggered, PMA (Phorbol Myristate acetate, acetylmyridrobol ester) can promote the proliferation and secretion of cytokines in normal human CD4⁺and CD8⁺Tlymphocytes in vitro.