Anti-Human CD20 mAb-T&L Biotechnology

Product manual COA

Anti-Human CD20 mAb

Price：$ 254

Size：

500μg

500μg

Product No.：GMP-TL502-0500

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Product Information

Expression Host：
CHO cells
QC Testing Purity：
> 90 % as determined by SDS-PAGE.
Purification：
Protein A purified from cell culture supernatant.
Biological activity：
The binding rate with PBMCs
Endotoxin：
< 0.1EU per μg of the protein as determined by the LAL method.
Formulation：
Supplied as a 0.22μm filtered solution in PBS, PH 7.4
Stability & Storage：
24 months at 2℃ to 8℃. Avoid repeated freeze-thaw cycles.

Background

CD20 is a specific signature molecule on the surface of B lymphocytes and is expressed on more than 95% of normal or malignant B lymphocytes. There is no expression of CD20 antigen in hematopoietic stem cells, progenitor cells, and other normal tissues. It consists of 297 amino acids with a molecular weight of 33 kD. CD20 has no internalization or cell surface shedding after binding with anti-CD20 mAb , which is an ideal antigen in the treatdment of B lymphocyte-related diseases. Anti-CD20 mAb can kill most of the lymphoma cells expressing CD20 molecules and normal B cells. Innate normal B cells are not affected by anti-CD20 mAb and can reconstruct B cell population. Therefore, anti-CD20 monoclonal antibodies are increasingly used in the treatment of B cell-related diseases.