Recombinant Human 4-1BB Ligand Protein

Price:$ 423/

Price:$ 701




Product No.:GMP-TL695-0050

Product No.:100μg / GMP-TL695-0100

Product Information

  • Expression Host:

    HEK293 cells

  • Synonym:

    4-1BB Ligand, TNFSF9, CD137L

  • Protein sequence:

    A DNA sequence encoding the human 4-1BB Ligand (NP_003802.1) was expressed with a Fc-tag at the C-terminus.

  • Molecular Mass:

    The recombinant human 4-1BB Ligand protein consists of 467 amino acids and predicts a molecular mass of 51 kD.

  • QC Testing Purity:

    > 90 % as determined by SDS-PAGE.

  • Endotoxin:

    < 0.1EU per 1 μg of the protein by the LAL method.

  • Activity:

    Measured by its ability to induce IL-8 secretion by PBMC. The ED₅₀ for this effect is ≤ 10 ng/mL.

  • Formulation:

    Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization.

  • Stability:

    24 months at 2℃ to 8℃ in lyophilized state.
    6 months at -20℃ under sterile conditions after reconstitution.
    12 months at -80℃ under sterile conditions after reconstitution.

  • Storage:

    Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100μg/mL.
    Avoid repeated freeze-thaw cycles.


4-1BB ligand (4-1BBL), also known as CD137L or TNFSF9, is a member of the tumor necrosis factor (TNF) family expressed on activated antigen-presenting cells. Its receptor, 4-1BB, is a member of the TNF receptor family expressed on activated CD4 and CD8 T cells. In response to 4-1BB Ligand binding, 4-1BB transduces a co-stimulatory signal that promotes the proliferation, activation, and survival of CD4⁺and CD8⁺T cells. T cell co-stimulation through CD28 is important for the initial T cell expansion, while 4-1BB acts later in the response. Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

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