Recombinant Human IL-21 Protein

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Product No.:GMP-TL509-0050

Product No.:GMP-TL509-0100

Product No.:GMP-TL509-1000(Customized)

Product Information

  • DMF filed no:


  • Expression Host:

    CHO cells

  • Synonym:

    CVID11, IL-21, Za11

  • Protein sequence:

    A DNA sequence encoding the extracellular domain of human IL-21(Q9HBE4-1: Q29-S162) was expressed with the C-terminal fused Fc region of human IgG1.

  • Molecular Mass:

    The recombinant human IL-21 predicts a molecular mass of 41.9kD.

  • QC Testing Purity:

    > 95 % as determined by SDS-PAGE.

  • Endotoxin:

    < 0.01 EU per μg of the protein as determined by the LAL method.

  • Activity:

    Measured by its ability of inducing human natural killer lymphoma NK-92 cells to secrete interferon-γ. The expected ED₅₀ is ≤ 50 ng/mL.

  • Formulation:

    Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization.

  • Stability:

    Lyophilized  preparation can be stored at -20 ℃.
    6 months at -20℃ under sterile conditions after reconstitution.
    12 months at -80℃ under sterile conditions after reconstitution.

  • Storage:

    Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100μg/mL.
    Avoid repeated freeze-thaw cycles.


IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation.Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include:inducing the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells; the stimulation of IgG production in conjunction with IL-4;and the induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally,IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells.IL-21 exerts its effect through binding to a specific type I cytokine receptor,IL-21R,which also contains the γ chain (γc) found in other cytokine receptors, including IL-2,IL-4,IL-7,IL-9 and IL-15.The IL-21/IL-21R interaction triggers a cascade of events,which includes activation of the tyrosine kinases JAK1 and JAK3,followed by activation of the transcription factors STAT1 and STAT3.

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