Recombinant Human IL-18 Protein

Price:$ 211

Price:$ 394




Product No.:GMP-TL902-0050

Product No.:GMP-TL902-1000(Customized)

Product Information

  • Expression Host:


  • Synonym:

    interleukin-18, Interleukin-1 gamma, IL1F4

  • Protein sequence:

    A DNA sequence encoding the human IL-18 (NP_001553.1) was expressed with no tag.

  • Molecular Mass:

    Predicts a molecular mass of 18.2 kD.

  • QC Testing Purity:

    > 90 % as determined by SDS-PAGE

  • Endotoxin:

    < 0.1EU per 1 μg of the protein by the LAL method.

  • Activity:

    Measured by its ability to induce IFN-γ secretion by KG‑1 cells in the presence of TNF-α. The ED₅₀ for this effect is 5-30 ng/mL.

  • Formulation:

    Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization.

  • Stability:

    Lyophilized  preparation can be stored at -20 ℃.
    6 months at -20℃ under sterile conditions after reconstitution.
    12 months at -80℃ under sterile conditions after reconstitution.

  • Storage:

    Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100 μg/mL. Avoid repeated freeze-thaw cycles.


IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and Th1 cell response. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, γδ T cells, and phagocytes. IL-18 is related to the IL-1 family in terms of both structure and function. In terms of structure, IL-18 and IL-1beta share significant primary amino acid sequences and are similarly folded as all-beta pleated sheet molecules. Also similar to IL-1beta, IL-18 is synthesized as a biologically inactive precursor molecule lacking a signal peptide. In the presence of IL-1 beta or IL-23, IL-18 induces the antigen-independent production of IL-17 by gamma δ T cells and CD4⁺T cells (11). IL-18 also promotes myeloid dendritic cell maturation and triggers neutrophil respiratory burst (12, 13). In cancer, IL-18 exhibits diverse activities including enhancing anti-tumor immunity, inhibiting or promoting angiogenesis, and promoting tumor cell metastasis.

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