Recombinant Human IL-12 Protein

Price:$ 462

Price:$ 732

Price:$ 1127





Product No.:GMP-TL508-0050

Product No.:GMP-TL508-0100

Product No.:GMP-TL508-1000 (Customized)

Product Information

  • Expression Host:

    HEK293 cells

  • Synonym:

    IL12, p70, Interleukin-12

  • Protein sequence:

    Recombinant human IL-12 is heterodimeric and composed of P29459-1 (IL12A) and P29460-1 (IL12B).

  • Molecular Mass:

    The Recombinant Human IL-12 Protein predicts a molecular mass of 65 kDa.

  • QC Testing Purity:

    > 90 % as determined by SDS-PAGE.

  • Endotoxin:

    < 0.1EU per 1 μg of the protein by the LAL method.

  • Activity:

    Measured by cell proliferation assay on PHA activated PBMC cells.The ED50 of this effect is ≤ 0.2 ng/mL.

  • Formulation:

    Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization.

  • Stability:

    24 months at 2℃ to 8℃ in lyophilized state.
    6 months at -20℃ under sterile conditions after reconstitution.
    12 months at -80℃ under sterile conditions after reconstitution.

  • Storage:

    Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100μg/mL. Avoid repeated freeze-thaw cycles.


IL-12 is primarily produced by monocytes, macrophages, B cells and DCs. IL-12 is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40).IL-12 receptors are located mainly on T cells and NK cells, and IL-12 can stimulate Th1 and NK cell growth, while inhibiting Th2 cell responses. IL-12 augments cytotoxicity of T lymphocytes and NK cells through the enhancement of IFN-γ and TNF-α secretion, and inhibition of IL-4 production.

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