Recombinant Human IL-6 Protein

Price:$ 352

Price:$ 507




Product No.:GMP-TL512-0050

Product No.:GMP-TL512-0100

Product Information

  • Expression Host:

    HEK293 cells

  • Synonym:


  • Protein sequence:

    A DNA sequence encoding the human IL-6(NP_000591.1:V30-M212)was expressed with a His-tag at the C-terminus.

  • Molecular Mass:

    The Recombinant Human IL-6 Protein predicts a molecular mass of 21.6 kD.

  • QC Testing Purity:

    > 90 % as determined by SDS-PAGE.

  • Endotoxin:

    < 0.1EU per μg of the protein as determined by the LAL method.

  • Activity:

    Determined by the dose-dependent stimulation of the proliferation of TF-1 cells,the activity is ≥2.0x10⁷U/mg

  • Formulation:

    Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization.

  • Stability:

    24 months at 2℃ to 8℃ in lyophilized state.
    6 months at -20℃ under sterile conditions after reconstitution.
    12 months at -80℃ under sterile conditions after reconstitution.

  • Storage

    Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100μg/mL.
    Avoid repeated freeze-thaw cycles.


Interleukin 6 (IL-6) produced by fibroblasts, monocytes, macrophages, T lymphocytes, B lymphocytes, epithelial cells,  keratinocytes and various tumor cells. IL-1, TNF-α, PDGF, viral infection, double stranded RNA, and cAMP can all induce normal cells produce IL-6. IL-6 can stimulate the proliferation, differentiation of immune responses and improve immune cell functions. IL-6R is widely expressed on the surface of activated B cells, quiescent T cells, NK cells, myeloma cells, hepatocytes, and myeloid leukemia cells. The main role of IL-6 is to promote the proliferation and differentiation of B cells and the secretion of antibodies. It also has extensive effects on liver cells, T cells, neural tissue, and hematopoietic system. IL-6 also has anti-tumor effects and can directly or indirectly enhance the tumoricidal activity of NK cells and CTL.

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