Recombinant Human IL-2 Protein ( high-efficiency )

Price:$ 42



Product No.:GMP-TL906-0100

Product Information

  • Generic Name:

    Recombinant Human IL-2 Protein

  • Expression Host:


  • Synonym:

    TCGF, lymphokine, Interleukin 2

  • Molecular Mass:

    The recombinant human IL-2 protein predicts a molecular mass of 15.4 kD.

  • QC Testing Purity:

    > 90 % as determined by SDS-PAGE.

  • Endotoxin:

    < 0.1EU per 1 μg of the protein by the LAL method.

  • Activity:

    Determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells ,corresponding to a activity of ≥1x10⁷U/mg.

  • Formulation:

    Lyophilized from sterile PBS, pH 7.4. Normally 6 % mannitol are added as protectants before lyophilization.

  • Stability:

    Lyophilized  preparation can be stored at 2-8 ℃.
    6 months at -20℃ under sterile conditions after reconstitution.
    12 months at -80℃ under sterile conditions after reconstitution.

  • Storage

    Recommend to aliquot the protein into smaller quantities after reconstituting with water for injection, normal saline or PBS, and keep the diluted concentration above 100μg/mL.
    Avoid repeated freeze-thaw cycles.


Activated T cells generally cannot survive for a long time in vitro culture, and the addition of IL-2 can promote their long-term and sustained proliferation. The surface of stationary T cells does not express IL-2R and does not respond to IL-2; T cells activated by mitogen or other stimuli can express IL-2R and become target cells of IL-2; IL-2 can also induce increased IL-2R expression in target cells. The expression of IL-2R on T cells is transient, generally reaching its peak 2-3 days after activation and disappearing around 6-10 days. With the disappearance of IL-2R, T cells lose their ability to respond to IL-2. Therefore, in order to maintain the long-term growth of normal T cells in vitro, it is necessary to constantly stimulate T cells with mitogen or other stimulators to maintain the expression of IL-2R. NK cells are the only lymphoid cells that normally express IL-2R, and therefore always maintain reactivity to IL-2. However, only IL-2R is expressed on stationary NK cells β Chain and γ Chains have a low affinity for IL-2 and can only react with high concentrations of IL-2. Once NK cells are activated, they express IL-2R α Chain, becoming a high affinity receptor.

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